1、In the course of time it told upon his temper.
一段時間以后，他的性情受到了影響。

2、In the course of time many empires have risen and fallen.
多少帝國興衰事，全在時光流逝中。

3、It is possible that in the course of time a cure for cancer will be found.
治療癌癥的方法終有一天能找到。

in the course of time翻譯